Blood cells that produces antibodies

Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies
Cells of the immune system

Antibodies can protect from Plasmodium falciparum (Pf) infection and clinical malaria disease. However, in the absence of constant reexposure, serum immunoglobulin (Ig) levels rapidly decline and full protection from clinical symptoms is lost, suggesting that B cell memory is functionally impaired. We show at the single cell level that natural Pf infection induces the development of classical memory B cells (CM) and atypical memory B cells (AtM) that produce broadly neutralizing antibodies against blood stage Pf parasites. CM and AtM contribute to anti-Pf serum IgG production, but only AtM show signs of active antibody secretion. AtM and CM were also different in their IgG gene repertoire, suggesting that they develop from different precursors. The findings provide direct evidence that natural Pf infection leads to the development of protective memory B cell antibody responses and suggest that constant immune activation rather than impaired memory function leads to the accumulation of AtM in malaria. Understanding the memory B cell response to natural Pf infection may be key to the development of a malaria vaccine that induces long-lived protection.

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  • Avatar Sierra How do white blood cells fight infection?
    May 27, 2009 by Sierra | Posted in Infectious Diseases

    I read that white blood cells can eat infection or produce antibodies to kill the disease. If this is true, what do they do with the infections once they eat them? And how do the antibodies work?

    • Eating them is simple way of explaining what they do to someone who has not had any biology training. The white cell surrounds and engulfs the bacteria cell then destroys it and the destroyed products are removed from th …. They can also produce antibodies which are specifically designed to go after a specific organism and destroy them. Once you have developed antibodies to an organism you will always have them (that's how vaccines work).